NCSTN polyclonal antibody
产品名称： NCSTN polyclonal antibody
英文名称： NCSTN polyclonal antibody
产品编号： PAB13232
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of NCSTN.
- Immunogen:
- A synthetic peptide corresponding to internal region 18 amino acids of human NCSTN.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
Nguyen V, Hawkins C, Bergeron C, Supala A, Huang J, Westaway D, St George-Hyslop P, Rozmahel R.Brain Res. 2006 May 1;1086(1):76-84. Epub 2006 Apr 13.
- 2.
- Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.
Periz G, Fortini ME.J Neurosci Res. 2004 Aug 1;77(3):309-22.
- 3.
- The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease.
Selkoe DJ.Trends Cell Biol. 1998 Nov;8(11):447-53.
- Entrez GeneID:
- 23385
- Protein Accession#:
- NP_056146
- Gene Name:
- NCSTN
- Gene Alias:
- APH2,KIAA0253
- Gene Description:
- nicastrin
- Omim ID:
- 605254
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
- Other Designations:
- ATAG1874,OTTHUMP00000031839,anterior pharynx-defective 2
- Gene Pathway