CDK4 monoclonal antibody, clone AF10A4
产品名称: CDK4 monoclonal antibody, clone AF10A4
英文名称: CDK4 monoclonal antibody, clone AF10A4
产品编号: MAB2700
产品价格: null
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围:
亚诺法生技股份有限公司(Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Mouse monoclonal antibody raised against full length recombinant CDK4.
- Immunogen:
- Recombinant MBP fusion protein corresponding to full length of human CDK4.
- Host:
- Mouse
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Ammonium sulfate precipitation
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy.
Takahashi-Yanaga F, Sasaguri T.Cell Signal. 2008 Apr;20(4):581-9. Epub 2007 Oct 23.
- 2.
- Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human.
Lee YM, Sicinski P.Cell Cycle. 2006 Sep;5(18):2110-4. Epub 2006 Sep 15.
- 3.
- Mammalian cyclin-dependent kinases.
Malumbres M, Barbacid M.Trends Biochem Sci. 2005 Nov;30(11):630-41. Epub 2005 Oct 19.
- Entrez GeneID:
- 1019
- Gene Name:
- CDK4
- Gene Alias:
- CMM3,MGC14458,PSK-J3
- Gene Description:
- cyclin-dependent kinase 4
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq
- Other Designations:
- cell division kinase 4,melanoma cutaneous malignant, 3
- Related Disease
- Adenocarcinoma
- Birth Weight
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Glioblastoma
- Head and Neck Neoplasms
- Kidney Failure, Chronic
- Leukemia, Lymphocytic, Acute, L1
- Lung Neoplasms
- Lymphoma, Non-Hodgkin
- Malignant melanoma
- Melanoma
- Mouth Neoplasms